Myocardium as contributor of plasminogen activator to blood.
نویسندگان
چکیده
The plasminogen activator content in the circulating blood has hitherto been thought to derive largely from the endothelium of the veins (Messer, Celander, and Guest, I962; Chakrabarti, Birks, and Fearnley, I963; Warren, I964), though this has been difficult to prove and several other hypotheses have been put forward. Pandolfi and his colleagues (i967), for instance, believe that the plasminogen activator is liberated from the vasa vasorum of the veins, and it has recently been suggested that the blood during its passage through the kidneys (Buluk and Furman, I962; Menon and Dewar, I967; Menon, I968a, b; Menon, Dewar, and Newell, g968b), muscles (Menon et al., I968a; Menon, i969), brain (Menon et al., I97ob), uterus (Maki et al., I965; Menon et al., I97oa), and stomach (Menon and Dewar, I970) receives this factor from the organs mentioned. It has further been suggested that the lymphatic system through its chyle is a potent contributor of this activator to the circulation (Menon, Weightman, and Dewar, 1970c). The present investigation was carried out in order to examine the part the myocardium might play in the contribution of activator to the blood. With this object we compared the plasminogen activator content in blood obtained from a coronary sinus with the activator content in blood from the right atrium and a femoral artery.
منابع مشابه
The brain as contributor of plasminogen activator to the blood.
1. A considerable increase in the plasminogen activator content in the internal jugular venous blood as compared with that in the arterial blood was found in fifty patients. 2. Inhalation of 5 % carbon dioxide in air was associated with increased plasminogen activator content in blood from the internal jugular vein in all the eight patients treated in this way. 3. It is suggested that the human...
متن کاملSerum Level of Plasminogen Activator Inhibitor Type-1 in Addicted Patients with Coronary Artery Disease
Background: Plasminogen activator inhibitor-1 (PAI-1) is a glycoprotein with inhibitory effects on the formation of plasmin from plasminogen by plasminogen activator. Thus, it prevents clot lysis in vessel walls. Several evidences prove the relationship between coronary artery disease and response to fibrinolytic therapy in patients with myocardial infarction with PAI-1 level. Opium addiction i...
متن کاملThe Effects of Regular Aerobic Exercise on the serum levels of Plasminogen Activator Inhibitor-1 and Adiponectin in Obese Girls
Background: The modification of the adipokine levels can be important for the long-term prevention of systemic inflammation related to obesity in children. Objective: The current study aimed to investigate the effects of regular aerobic exercise on the serum levels of plasminogen Activator inhibitor-1(PAI-1) and Adiponectin in obese girls. Methods: This semi experimental research, 14 obese gi...
متن کاملOptimizing refolding condition for recombinant tissue plasminogen activator
Low molecular size additives such as L-arginine and the redox compounds have been used both in the culturemedium and in vitro refolding to increase recombinant proteins production. Additives increase proteinrefolding and yield of active proteins by suppressing aggregate formation or enhancing refolding process.In this work, a comparative study was performed on refolding of rec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- British heart journal
دوره 33 3 شماره
صفحات -
تاریخ انتشار 1971